Hamster-tropic sarcomagenic and nonsarcomagenic viruses derived from hamster tumors induced by the Gross pseudotype of Moloney sarcoma virus.
نویسندگان
چکیده
Hamster sarcomas induced by the Gross pseudotype of Moloney sarcoma virus yielded a virus sarcomagenic for hamsters but not mice. This virus was able to produce foci on hamster embryo cells, but not on mouse embryo cells. A hamster-tropic nonfocus-forming helper virus was also found in the viral stocks. These hamster-tropic viruses are not immunologically related to the murine viruses in the original inoculum but appear to represent indigenous C-type RNA viruses of the hamster.
منابع مشابه
Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses.
Hartley and Rowel reported that the in vitro focus-forming effects of Moloney sarcoma virus (MSV)2 I depended on the presence in the same cells of two virus particles, a defective i\ISV particle and a fully infectious Moloney leukemia particle. Superinfection with additional Moloney leukemia virus potentiated focus formation by MSV, converting a "two-hit" dose response curve to a one-hit curve;...
متن کاملBiologic studies on hamster tumors induced by the murine sarcoma virus (Moloney).
SUMMARY Hamsters inoculated with murine sarcoma virus (Moloney) of mouse or rat origin developed nonregressing, metastasizing, undifferentiating sarcomas. Light microscopy and ultrastructural studies of the hamster sarcoma revealed less tumor-cell differentiation than reported for the mouse or rat. Cell-free extracts prepared from the hamster tumors were oncogenic only in animals of the same sp...
متن کاملCell line derived from a murine sarcoma virus (Moloney Pseudotype)-induced tumor: cultural, antigenic, and virological properties.
A cell line derived from a murine sarcoma virus (Moloney pseudotype)-induced tumor has been established. It retains oncogenicity, releases both sarcoma and leukemia viruses, and has virus-induced cellular antigens.
متن کاملA Classification of the Murine Leukemia Viruses
Coinfection of neonatal BALB/c mice with helper-dependent Friend spleen focus-forming virus (SFFV), as contained in the Friend virus (FV) complex, and antigenically distinct Moloney leukemia virus (MolLV) resulted in the recovery of a MolLV pseudotype of SFFV, abbreviated SFFV(MolLV). The antigenic alteration of SFFV was observed by following its neutralization kinetics in vitro by specific Fri...
متن کاملProperties of noninfectious and transforming viruses released by Murine sarcoma virus-induced hamster tumor cells.
The cell culture lines HTG2 and HTG3 were established from a transplantable hamster tumor induced by a murine sarcoma virus (strain Gz-MSV) after 17 and 60 in vivo passages, respectively. The viruses released by these two cell lines markedly differ in morphology, antigenic composition, infectivity, transforming ability, and enzymatic activity. HTG2 virions contained the sarcoma genome but were ...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 65 2 شماره
صفحات -
تاریخ انتشار 1970